Internalization of radiolabelled [DTPA0]octreotide and [DOTA0, Tyr3]octreotide
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چکیده
منابع مشابه
Internalization and catabolism of radiolabelled antibodies to the MHC class-II invariant chain by B-cell lymphomas.
The fate of antibody (Ab) LL1, which reacts with the invariant chain (Ii) subunit of the immature MHC class-II antigen (CD74) after binding to the surface of B-cell lymphomas was investigated. This Ab was internalized and catabolized very rapidly, much faster than other Abs that are considered to be rapidly internalized, such as CD19, CD22 and anti-(transferrin receptor). Such internalization d...
متن کاملPreclinical pharmacokinetics of radiolabelled hyaluronan.
BACKGROUND Hyaluronan (HYA) is a high molecular weight glucosaminoglycan with a great perspective for medical applications. Because HYA is widespread in the body, it is difficult to determine the fate of exogenously administered HYA. METHODS In this study, HYAof different molecular weights (0.1-1 MDa) was labelled with (99m)Tc, and the distribution profiles were determined after administratin...
متن کاملCancer imaging with radiolabelled antibodies and peptides.
Radiology requires a mass of tissue, displacing tissue, infiltrating tissue, for contrast. Nuclear Medicine does not require a mass. It exploits the subtle differences between the cancer cell and the normal cell for identification. There is also an amplification factor. For example, antigen expression may be 500–50,000 per cell and receptor expression may be between 500 and 10,000 per cell. The...
متن کاملpostnatal studies of bats (pipistrellus kuhlii and miniopterus schreibersii) & histomorphology and histochemistry studies of organs and diseases of (neurergus microspilotus and n. kaiseri)
1. to determine whether difference in birth body mass influenced growth performance in pipistrellus kuhlii we studied a total of 12 captive-born neonates. bats were assigned to two body mass groups: light birth body mass (lbw: 0.89 ± 0.05, n=8) and heavy birth body mass (hbw: 1.35 ± 0.08, n=4). heavier body mass at birth was associated with rapid postnatal growth (body mass and forearm length) ...
Gastric emptying of two radiolabelled antacids.
The rate of gastric emptying of two antacids, magaldrate and Maalox, was investigated using scintigraphy. Successful labelling of the antacids was carried out with 99mTc. The stability of the 99mTc-labelled antacids was satisfactory and there was no difference in antacid capacity between the labelled and unlabelled antacids. The studies were carried out on 15 healthy male volunteers. After an e...
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ژورنال
عنوان ژورنال: Nuclear Medicine Communications
سال: 1998
ISSN: 0143-3636
DOI: 10.1097/00006231-199803000-00013